Striatal dopaminergic patterns and clinical features in frontotemporal dementia.

ABSTRACT: Frontotemporal dementia is a group of neurodegenerative disorders mainly characterized by behavioural and language impairments. While the precise pathophysiology remains elusive, emerging evidence points to an important role of dopamine dysfunction, particularly within the caudate nucleus. Moreover, a theoretical model proposes that frontotemporal dementia manifestations result from a deficit in goal-directed behaviour, which may be related to altered dopamine control of the frontostriatal circuitry. However, no study has investigated the gradient of striatal dopamine transporter levels in frontotemporal dementia using neuroimaging and their correlation with clinical features. This study used ¹²³I-Ioflupane Single Photon Emission Computed Tomography imaging to measure striatal d

SUBMITTER: Urso D 

PROVIDER: S-EPMC12365758 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature