Major depressive disorder and anti-depressant therapy markedly alters the human follicular niche DNA methylome.

ABSTRACT: Generalized anxiety disorder, major depressive disorder and their treatment selective serotonin reuptake inhibitors (SSRIs) impact 4-17% of pregnancies worldwide and alter the epigenome of numerous tissues, but their effects on the ovarian follicle are unknown. This study profiles the methylome of granulosa cells, revealing novel epigenetic pathways and molecular mechanisms altered by mental health conditions and their treatments. Generalized anxiety and major depressive disorders (GAD/MDD) impact 4-17% of pregnancies worldwide. GAD/MDD and SSRIs alter the epigenome of numerous tissues; however, their effect on the ovarian follicular niche is unknown. In this study, we determined SSRI concentrations in the follicular fluid and matched patients by clinical and stimulation characteristics, a

SUBMITTER: Fuchs Weizman N 

PROVIDER: S-EPMC12365779 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature