Biomimetic Model for Electromagnetic Modulation of Cardiovascular Cellular Interactions On-Chip.

ABSTRACT: Cardiovascular diseases are the leading cause of global mortality. These conditions are associated with cardiac cell death and loss of vascularization, potentially progressing to fatal myocardial infarction. However, the lack of accurate models to simulate the complex cardiac tissue microenvironment and explore alternative therapeutics contributes to heart disease still being regarded as irreversible. In this work, we developed a unique organ-on-chip platform that integrates electrical, magnetic, and mechanical stimulation to replicate the cardiac microenvironment and investigate the impact of electrical and magnetic stimulation on cardiac cell fate. Our micromodel integrated triple stimulating inputs using hybrid stimuli-responsive materials. Electromagnetic scaffolds were obtained by coa

SUBMITTER: Manjua AC 

PROVIDER: S-EPMC12365882 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature