Design of Injectable Nanocomposite Hydrogels for Controlled Release of Nanoparticles.

ABSTRACT: Nanocomposite hydrogels, i.e.; a combination of hydrogels and nanoparticles, have emerged as a promising platform for drug delivery owing to the high degree of design flexibility. Despite the wealth of literature on nanocomposite hydrogels, there is scant experimental data on the release of drug-loaded nanoparticles from hydrogels. Here, we report on the incorporation and subsequent release of dye-loaded nanoparticles from alginate-based hydrogels. We investigated the rheological properties of alginate and alginate-poly(ethylene oxide) hydrogels as a function of nanoparticle loading, as well as the time-dependent nanoparticle release profiles. The effects of hydrogel compositional parameters and nanoparticle loading on viscosity and release profiles were investigated using pr

SUBMITTER: Glomm WR 

PROVIDER: S-EPMC12365918 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature