Metabolomics and nutrient intake reveal metabolite-nutrient interactions in metabolic syndrome: insights from the Korean Genome and Epidemiology Study.

ABSTRACT:

Background

Despite advances in metabolomics, the complex relationship between metabolites and nutrient intake in metabolic syndrome (MetS) remains poorly understood in the Korean population.

Objective

This study aimed to characterize the metabolomic profiles and nutrient intake associated with MetS and to examine their relationships in the Ansan-Ansung cohort of the Korean Genome and Epidemiology Study (KoGES).

Methods

Data from 2,306 middle-aged adults (1,109 men and 1,197 women) in the KoGES Ansan-Ansung cohort were analyzed. Plasma metabolites were measured using liquid chromatography-mass spectrometry, identifying 135 metabolites. Nutrient intake was assessed using a validated semi-quantitative food frequency questionnaire covering 23 nutrients. MetS-associated me

SUBMITTER: Kim M 

PROVIDER: S-EPMC12366009 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature