Trans-omics analyses identify the biochemical network of LPCAT1 associated with coronary artery disease.

ABSTRACT:

Background

Coronary artery disease (CAD) remains a leading cause of mortality in developed nations. While previous genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) linked to CAD, their impact on disease progression requires trans-omics validation.

Methods

This study merges whole genome SNP analysis and metabolomic profiling to distinguish CAD patients from high-risk and healthy individuals. A cross-sectional study was conducted, enrolling participants from the Northeastern Taiwan Community Medicine Research Cohort, which spans the period between August 2013 and November 2020. A total of 781 participants were included in the study and categorized into three groups: control (n = 271), high-risk (n = 363), and CAD (n = 147) groups, followin

SUBMITTER: Hsu PW 

PROVIDER: S-EPMC12366056 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature