Effect of discontinuing antipsychotic medications on the risk of hospitalization in long-term care: a machine learning-based analysis.

ABSTRACT:

Background

Antipsychotic medications are frequently prescribed to older residents of long-term care facilities (LTCFs) despite their limited efficacy and considerable safety risks. While discontinuation of these drugs might help reduce their associated morbidity, the impact of stopping antipsychotics on the risk of hospitalization has not been studied yet. The study aimed at estimating the effect of antipsychotic discontinuation on the risk of hospitalization in older LTCF residents and at identifying relevant factors influencing such effect.

Methods

For this registry-based retrospective cohort study, data from a cohort of older LTCF residents in Finland from the years 2014 to 2018 was analyzed. Data sources were the Resident Assessment Instrument for Long-Term Care (RAI-LTC

SUBMITTER: Nuutinen M 

PROVIDER: S-EPMC12366079 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature