Combining mindfulness intervention and open-label placebo treatment for chronic pain: a protocol for a feasibility study.

ABSTRACT:

Background

Mindfulness-based interventions, such as mindfulness-based stress reduction (MBSR), are efficacious mind-body treatments for chronic pain, though their modest effect sizes suggest room for improvement. Notably, recent studies indicate that mindfulness meditation does not engage the endogenous opioid system, which plays an important role in analgesia. Therefore, exploring the combination of a mindfulness-based intervention with a non-opioid treatment that activates this system is warranted. Open-label placebo (OLP), a placebo that is given to a participant without deception, has shown significant promise as a safe and potentially effective analgesic, with studies indicating its effects are mediated by the release of endogenous opioids. This study aims to evaluate the feas

SUBMITTER: Mun CJ 

PROVIDER: S-EPMC12366083 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature