Bioengineered cardiovascular bypass grafts via in vivo self-assembly of scaffold-guided tubular tissue in rats.

ABSTRACT: Cardiovascular bypass grafting remains a crucial therapeutic approach for complex atherosclerotic diseases. However, the clinical application of traditional grafts is hampered by limited autologous vessel availability, while the translational potential of fully cellular self-assembled vascular grafts is constrained by their prolonged fabrication. Here, we present a scaffold-guided in vivo tubular tissue self-assembly strategy to rapidly engineer functional cardiovascular bypass grafts. Using 3D-printed biodegradable scaffolds implanted subcutaneously in SD rats, we generated bioengineered tubular vascular constructs (BTCs) rich in host cells and extracellular matrix within 2 weeks. BTC exhibited biophysical and biochemical properties highly analogous to the native abdominal aorta. When use

SUBMITTER: Hu S 

PROVIDER: S-EPMC12366095 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature