Correlation between gut microbiota and metabolomics under intermittent hypoxic conditions.

ABSTRACT: This study investigates the role of gut microbiota and metabolites as biomarkers in the diagnosis and assessment of Obstructive Sleep Apnea (OSA) by analyzing the correlation between microbiota and metabolomics in the host's gut under conditions of chronic intermittent hypoxia (CIH). We analyzed the composition and function of gut microorganisms and metabolites in OSA and CIH mouse models using 16S rRNA sequencing combined with targeted metabolomics to evaluate the association between clinical indicators and severity of OSA and gut flora and metabolites. Compared with normal controls, we found: (1) The apnea hypoventilation index (AHI) and fasting blood glucose were higher in the moderate and severe OSA groups, the eosinophilia score (EP) and neutrophil percentage were significantly higher

SUBMITTER: Zeng T 

PROVIDER: S-EPMC12366097 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature