Dataset Information
Insight into blood proteinase-inhibitor system and pathogenesis of renal tuberculosis induced by phylogenomically different Mycobacterium tuberculosis strains in rabbit model.
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ABSTRACT:
SUBMITTER: Esmedlyaeva D
PROVIDER: S-EPMC12366148 | biostudies-literature | 2025 Aug
REPOSITORIES: biostudies-literature
Publications
Insight into blood proteinase-inhibitor system and pathogenesis of renal tuberculosis induced by phylogenomically different Mycobacterium tuberculosis strains in rabbit model.
BMC nephrology 20250820 1
BACKGROUND: This study aimed to evaluate the impact of different Mycobacterium tuberculosis strains on the blood proteinase-inhibitor system and structural changes in the renal parenchyma during the pathogenesis of renal tuberculosis in a rabbit model. METHODS: Renal tuberculosis was modeled on 60 male Soviet Chinchilla rabbits. The susceptible virulent strain M. tuberculosis H37Rv (Euro-American lineage, group 1) and the low-lethal multidrug-resistant strain 5582 (Beijing Central Asian/Russian ...[more]