The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells.

ABSTRACT: The oxidative stress and apoptosis of renal tubular epithelial play an important role in the progression of diabetic nephropathy. Blocking oxidative stress and apoptosis of renal tubular epithelial could be a novel therapeutic target for diabetic nephropathy. Kaempferol (KMP), a natural phytoestrogen and common dietary flavonoid, has various biological effects including anti-oxidation, anti-apoptosis and anti-inflammation. KMP has protective effect against oxidative stress-related diseases, such as ischemia-reperfusion induced myocardium injuries, osteoporosis, obesity and so on. In our research, we observed the influence of KMP on high glucose (HG) cultured HK-2 cells and explored its mechanisms from the aspect of oxidative stress and apoptosis. To find out the safety and effective concen

SUBMITTER: Jiao XC 

PROVIDER: S-EPMC12366318 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature