Synthetic lipopeptides that interact with lipopolysaccharides are potent bactericidal compounds against <i>Xylella fastidiosa</i>.

ABSTRACT: Novel strategies to control diseases caused by Xylella fastidiosa that affect important crops like grapevine, olive, almond, and citrus are necessary to prevent its establishment and spread in several countries. Target-oriented functional peptides toward the pathogen are potential new compounds, and peptides directed to lipopolysaccharides (LPS) are suitable candidates. In the present work, 36 peptides, including previously reported sequences and newly synthesized lipopeptides, were studied for their bactericidal and LPS neutralization activities, as well as for their hemolytic and phytotoxic activities. In a first stage, a simple and rapid method for detecting peptide-LPS interactions based on a chromogenic endotoxin assay was developed. A linear relationship was observed between L

SUBMITTER: Caravaca-Fuentes P 

PROVIDER: S-EPMC12366332 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature