Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function.

ABSTRACT: Sanren Decoction (SRD), a traditional Chinese medicine formula historically used to relieve damp-heat and gastrointestinal disorders, demonstrates targeted efficacy in ulcerative colitis (UC)-a disease marked by chronic inflammation and mucosal damage-by acting on multiple pathological pathways. This study employed an integrative methodology comprising network pharmacology, molecular docking, and in vivo experimentation to elucidate the underlying pharmacological mechanisms of SRD in the management of UC. The findings identified 87 genes targeted by SRD that are associated with UC, highlighting PTGS2 (Prostaglandin-Endoperoxide Synthase 2) as a crucial target involved in inflammatory processes. Molecular docking analysis confirmed significant interactions between the active compounds of SR

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12366350 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature