Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) remains a global health burden, with disproportionately high mortality in China's Guangxi region, where endemic Clonorchis sinensis (C. sinensis) infection coincides with elevated HCC incidence. Preliminary single-cell sequencing revealed marked overexpression of cluster of differentiation 24 (CD24) in HCC tissues, suggesting its potential pathological role. This study aims to elucidate the oncogenic mechanisms of C. sinensis excretory-secretory products (CsESPs) and their link to CD24-mediated HCC progression.

Methods

We employed an integrated clinical and experimental approach. First, clinical cohort analysis assessed CD24 expression in C. sinensis-associated HCC cases. Multiplatform bioinformatics validation (GEPIA/UALCAN/TIMER) e

SUBMITTER: Lu WM 

PROVIDER: S-EPMC12366411 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature