Effects of FAP⁺ cancer-associated fibroblasts on anti-PD-1 immunotherapy and CD4⁺ T cell polarization in gastric cancer.

ABSTRACT: Aim: The immune evasion mechanisms of gastric cancer are complex, involving various cellular dysfunctions within the tumor microenvironment. Recently, there has been growing interest in how cancer-associated fibroblasts (CAFs) contribute to tumor immune evasion. However, the precise molecular pathways through which CAFs drive immune escape in the context of gastric cancer are not yet fully elucidated. Methods: The abundance of FAP+CAFs in gastric cancer tissues was assessed by immunohistochemistry (IHC), and its correlation with tumor sensitivity to PD-1 monoclonal antibody therapy was analyzed. To study the effect of FAP+CAFs on naive CD4+ T cell differentiation, co-culture experiments were conducted. The underlying molecular mechanisms were further investigated through western blotting a

SUBMITTER: Wu J 

PROVIDER: S-EPMC12366491 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature