Phillyrin prevents calcium oxalate kidney stones through the PPARγ signaling pathway.

ABSTRACT:

Background

Nephrolithiasis is a significant health issue causing pain, hypertension, and chronic kidney disease. Phillyrin, a bioactive compound from Forsythia suspensa, may offer therapeutic benefits against these conditions. The study was focused on phillyrin efficacy on alleviating kidney stone formation and associated damage.

Methods

HK-2 cells were exposed to calcium oxalate (CaOx) to generate an in vitro kidney cell injury model. The kidney stones were induced in rats by 1% ethylene glycol and 2% ammonium chloride. Cell viability was assessed by CCK-8 assay. Cell apoptosis was detected by JC-1 mitochondrial membrane potential assay. ROS and MDA contents and the activity of SOD and GSH-Px were assayed using matched assay kits. Differentially expressed gene

SUBMITTER: Chu X 

PROVIDER: S-EPMC12366511 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature