Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma.

ABSTRACT:

Background

Metastasis represents the primary cause of cancer-related mortality, with a high incidence observed in renal cell carcinoma (RCC). Anoikis, a specialized form of apoptosis, plays a crucial role in preventing displaced cells from adhering to new extracellular matrices (ECM), thus inhibiting their aberrant growth. Notably, cancer cells, especially metastatic ones, exhibit resistance to anoikis. However, the exact mechanisms of anoikis resistance in RCC are not well understood.

Methods

This study integrates bioinformatics, single-cell RNA sequencing and experimental validation to investigate the role of anoikis-related genes (ARG) in RCC, with a focus on MMP9. RNA-seq data from 518 RCC patients and 71 healthy controls (TCGA-KIRC) and external validation cohorts (E-MT

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12366518 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature