Histological synovitis and radiographic damage in knee osteoarthritis: insights from a comprehensive analysis of ultrasound-guided synovial biopsies in 161 patients.

ABSTRACT:

Objective

Synovial inflammation plays a crucial role in osteoarthritis (OA) by producing key cytokines that mediate synovium-cartilage interaction and drive damage progression. In this study, we aimed to evaluate relationships between histological features of synovitis, radiographic damage and patients' clinical characteristics.

Methods

This observational cross-sectional study included consecutive patients with knee OA from 2016 to 2022. Enrolled patients were aged between 40 and 90 years, had chronic knee pain lasting at least 3 months and showed ultrasound evidence of synovitis. All patients underwent a general rheumatological evaluation, including the collection of clinical and laboratory data and ultrasound (US)-guided minimally invasive synovial tissue biopsy. The sever

SUBMITTER: Rubortone P 

PROVIDER: S-EPMC12366559 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature