Association of PFAS and Metals with Cardiovascular Disease Risk: Exploring the Mediating Effect of Diet.

ABSTRACT: Cardiovascular disease (CVD) is a major global health burden influenced by genetic, behavioral, and environmental factors. Among these, exposure to per- and poly-fluoroalkyl substances (PFASs) and toxic metals has been increasingly implicated in adverse cardiovascular outcomes. However, the mediating role of dietary inflammation in these associations remains unclear. This study investigates the relationship between PFAS and metal exposures and CVD risk, focusing on the potential mediating role of diet, operationalized through the Dietary Inflammatory Index (DII). Additionally, this study examines age as an effect modifier in these associations. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 cycle (n = 660), we assessed environmental exposures (l

SUBMITTER: Odediran A 

PROVIDER: S-EPMC12366770 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature