<i>Helicobacter pylori</i> base-excision restriction enzyme in stomach carcinogenesis.

ABSTRACT: Many recent lines of evidence from the human microbiome and other fields indicate bacterial involvement in various types of cancer. Helicobacter pylori has been recognized as the major cause of stomach cancer (gastric cancer), but the mechanism by which it destabilizes the human genome to cause cancer remains unclear. Our recent studies have identified a unique family of toxic restriction enzymes that excise a base (A: adenine) from their recognition sequence (5'-GTAC). At the resulting abasic sites (5'-GT_C), its inherent endonuclease activity or that of a separate endonuclease may yield atypical strand breaks that resist repair by ligation. Here, we present evidence demonstrating involvement of its H. pylori member, HpPabI, in stomach carcinogene

SUBMITTER: Fukuyo M 

PROVIDER: S-EPMC12366791 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature