Effect of Allopurinol Use on Kidney Function Among Patients with Gout and Chronic Kidney Disease.

ABSTRACT: The evidence regarding allopurinol's effects on renal function among people with hyperuricemia and gout has been conflicting, though clinicians are often cautious about using allopurinol in chronic kidney disease (CKD). We sought to examine the relation between allopurinol use in those with gout and CKD and the risk of worsening renal function. We conducted a time-stratified propensity score (PS)-matched cohort study on the IQVIA Medical Research Data representative of the UK general population. Among participants 18-89 years old with gout and CKD 3-4 not on urate-lowering therapy within one year prior, we identified new users of allopurinol and matched them 1:1 with a non-user. We analyzed the relation between incident allopurinol use and the changes in the eGFR at one year of follow-up u

SUBMITTER: Vargas-Santos AB 

PROVIDER: S-EPMC12366798 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature