Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina.

ABSTRACT:

Purpose

Retinal degeneration is a common cause of blindness, but there is a gap in our understanding of the molecular mechanisms causing degeneration. Dysregulated PRDM13 has been linked to retinal dystrophy, indicating a role for PRDM13 in the retina. PRDM13 knockout studies have shown that PRDM13 specifies amacrine cell fates, but no studies have shown the phenotypic and mechanistic outcomes of its elevated activity in the retina.

Methods

We developed a mouse model to induce aberrant PRDM13 expression in a controlled, time-dependent manner. ERG and histological analyses were performed to determine whether elevated PRDM13 impacted the health and function of the retina. RNA sequencing of retinas with and without elevated PRDM13 defined transcriptional changes in response to

SUBMITTER: Nettesheim ER 

PROVIDER: S-EPMC12366859 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature