Effectiveness and safety of bivalirudin anticoagulation therapy in adult patients receiving extracorporeal membrane oxygenation: A systematic review and meta-analysis.

ABSTRACT:

Background

Compared to heparin, there is limited evidence of the benefits of bivalirudin in the patients with extracorporeal membrane oxygenation (ECMO).

Methods

We searched for studies comparing bivalirudin anticoagulation with heparin anticoagulation in ECMO patients in the PubMed, Embase, and Cochrane Library databases from inception to March 28, 2024. ECMO patients were divided into the bivalirudin experimental group and the heparin control group. Collected data were mortality rate, duration of ECMO, successful decannulation rate, incidence of thrombotic events, incidence of bleeding events, activated partial thromboplastin time values, platelet transfusion requirements, and other indicators for ECMO patients in the bivalirudin and heparin groups. StataMP17 and RevMan 5.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12366896 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature