Correlation between Neurotransmitter Transporter Gene Variants and Childhood Autism Spectrum Disorder: A Case-control Study.

ABSTRACT:

Objective

This case-control study aimed to determine the correlation between single nucleotide polymorphisms (SNPs) in the neurotransmitter transporter genes SLC6A3 and SLC6A4 and childhood autism spectrum disorder (ASD), as well as the severity of the disease.

Patients and methods

Children with ASD and age- and sex-matched healthy controls were recruited from a hospital and schools, respectively. Seven SNPs in the SLC6A3 gene and three SNPs in the SLC6A4 gene were analyzed in blood cell DNA using the TaqMan probe approach. The severity of the disease was evaluated using the Childhood Autism Rating Scale (CARS).

Results

A total of 249 children with ASD and 343 controls were included. The genotype frequencies of the examined SNPs were not co

SUBMITTER: Shen C 

PROVIDER: S-EPMC12366910 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature