The potential causal relationship between fat mass in different body areas and low back pain: Findings from NHANES and Mendelian randomization studies.

ABSTRACT: The purpose of this study is to investigate and discuss the potential relationship between fat distribution in different body regions and low back pain (LBP). We used 2 research methods to study the impact of fat distribution on LBP. First, we conducted a cross-sectional study using National Health and Nutrition Examination Survey data to examine the relationship between fat levels in the trunk and lower limbs and LBP. Second, we employed a two-sample Mendelian randomization approach to investigate the causal relationship between trunk fat, lower limb fat, and LBP. In the cross-sectional study, the results of multivariable logistic regression analysis showed that for every unit increase in trunk fat mass (FM) (kg), the risk of LBP increased by 2.8% (odds ratios, OR = 1.028, 95% confidence

SUBMITTER: Yang J 

PROVIDER: S-EPMC12366917 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature