Causal associations between fibroblast growth factors and breast cancer: Evidence from 2-sample Mendelian randomization analysis.

ABSTRACT: Previous studies have suggested a potential association between fibroblast growth factors (FGFs) and breast cancer (BC), but the evidence for the relationship between specific FGFs with BC is limited and controversial. To explore the interactions between 13 FGFs and 3 fibroblast growth factor receptors (FGFRs) with BC and its subtypes (ER+ and ER-), we conducted a Mendelian randomization (MR) analysis based on genome-wide association study summary statistics of European ancestry. Several techniques were used to ensure the stability of the causal effect, such as inverse-variance weighting, weighted median, MR-Egger regression, and Mendelian Randomization Pleiotropy Residual Sum and Outlier. Heterogeneity was assessed by calculating the Cochran's Q value. The inverse-variance weighting analy

SUBMITTER: Feng F 

PROVIDER: S-EPMC12366922 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature