Gut microbiota and childhood asthma: A 2-sample bidirectional Mendelian randomization study.

ABSTRACT: The causal relationship linking the human gut microbiota to childhood asthma remains inadequately defined. A bidirectional, 2-sample Mendelian randomization (MR) analysis was therefore conducted to investigate this potential causal association. Utilizing publicly accessible genome-wide association study summary data, we applied 2-sample MR to infer causality. The primary causal effect estimates were generated through inverse variance weighted meta-analysis. Sensitivity analyses included the weighted median, MR-Egger, and MR pleiotropy residual sum and outlier approaches. Robustness and evidence for pleiotropy were assessed using Cochran Q test, the MR-Egger intercept test, and leave-one-out sensitivity analysis. To investigate potential reverse causation, we performed a reverse MR analysis

SUBMITTER: Li Y 

PROVIDER: S-EPMC12366925 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature