Unveiling the enigma: Investigating the controversy surrounding mitochondrial DNA copy number and gastric cancer using Mendelian randomization analysis.

ABSTRACT: Gastric cancer (GC), as one of the most prevalent malignant tumors, significantly impacts individuals' health. Many studies have examined the relationship between mitochondrial DNA (mtDNA) copy number and GC. However, conclusions remain inconclusive, with conflicting findings. The genome-wide association study summary statistics for mtDNA copy number were obtained from 2 sources: one from a robust cohort of 465,809 White individuals provided by the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the UK Biobank; and the other from a dataset comprising 395,718 UK Biobank participants. In addition, a total of 5 sets of genome-wide association study summary statistics for GC were obtained through datasets from Finland, the European Bioinformatics Institute, and the

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12366980 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature