Granzyme B as a potential biological target in toxic encephalopathy: A big data-based exploratory analysis.

ABSTRACT: Toxic encephalopathy is a central nervous system disorder caused by endogenous or exogenous toxic substances. Granzyme B (GZMB), a key serine protease, plays a crucial role in immune regulation and the progression of various diseases. Abnormal expression of GZMB may contribute to the development and progression of toxic encephalopathy; however, its specific mechanisms remain unclear. This study aims to preliminarily explore the association between granzyme B and toxic encephalopathy through big data. This study retrieved the toxic encephalopathy dataset GSE253309 from the gene expression omnibus database. Differentially expressed genes were identified using the "limma" R package, followed by gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses. A protein-protein in

SUBMITTER: Liu L 

PROVIDER: S-EPMC12367007 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature