Causal association between gut microbiota and neonatal digestive system diseases: A Mendelian randomization study.

ABSTRACT: To delve into the underlying causal connections that may exist between the intestinal flora and disorders of the neonatal digestive system (DSD), aiming to identify specific pathogenic bacteria associated with the development and progression of neonatal DSD. We collected summary statistics from genome-wide association studies on neonatal DSD and gut microbiome-related phenotypes from the Finngen and MiBioGen consortia. We conducted a bidirectional, two-sample Mendelian randomization (MR) analysis to detect causal relationships between the gut microbiome and neonatal DSD. Data on 211 gut microbiome species were obtained from samples of various ethnicities (16,380,466 samples). DSD data were sourced from 143 cases and 218,649 control samples of European ancestry. Single nucleotide polymorphi

SUBMITTER: Pang J 

PROVIDER: S-EPMC12367028 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature