Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function.

ABSTRACT: Causal relationship between sleep duration and cognitive function remains unclear. This study used a two-sample Mendelian randomization (MR) analysis to assess the causal relationship between self-reported short sleep duration, insomnia and long sleep duration and cognitive function. A total of 26 single nucleotide polymorphisms (SNPs) associated with short sleep duration, 240 associated with insomnia, and 7 associated with long sleep duration were extracted from a genome-wide association study primarily based on European ancestry, to be used as instrumental variables. Summary-level statistics were obtained from the Dementia genome-wide association studies database. MR estimation was performed using the inverse variance weighted (IVW) method as the primary method, supplemented by MR-Egger

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12367179 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature