Evolution and Spread of Y280-Lineage H9N2 Low Pathogenicity Avian Influenza Viruses in Korea, 2020-2023.

ABSTRACT: In 2020, Y280-lineage H9N2 low pathogenic avian influenza was detected in South Korea for the first time. Active surveillance from live bird markets (LBMs) and farms revealed the continuous circulation of Y280-lineage H9N2 viruses, replacing the previously indigenous Y439-lineage and becoming dominant in South Korea. Antigenic mapping showed a substantial antigenic difference between the Y280 and Y439-lineage viruses. Bayesian phylodynamic approach suggests the introduction of Y280-lineage viruses from China and revealed the frequent exchange of viruses between LBM and farms. The presence of mammalian adaptation markers and high binding affinity to human-type sialic acid receptor raise a concern on interspecies transmission of the viruses to mammals. These findings underscore the importanc

SUBMITTER: Cho AY 

PROVIDER: S-EPMC12367370 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature