Early-Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High-Fat Diets.

ABSTRACT: Previous studies have identified early life as a sensitive window for BPA exposure that may increase the risk of metabolic disease in adulthood. However, less attention has been paid to the effects of early-life BPA exposure on the pancreas and its relationship to the development of metabolic diseases. In this study, we exposed females to 50 μg/kg/d BPA in drinking water from 6 days of gestation to weaning of offspring mice and administered a high-fat diet after weaning of offspring mice. We found that early-life BPA-exposed male mice gained body weight, had downregulated pancreatic Ins1, Pdx1, and NeuroG3 gene expression, reduced β-cell mass, and resulted in abnormalities in glucose tolerance and insulin tolerance, whereas no significant alterations were observed in f

SUBMITTER: Chen F 

PROVIDER: S-EPMC12367390 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature