Low serum testosterone is associated with an increased risk of first-time renal calculi in men without testosterone replacement therapy.

ABSTRACT: The incidence of low serum testosterone has been increasing in men of all ages across a period which also corresponds to an increasing prevalence of kidney stones. Currently, the relationship between testosterone and kidney stones is unclear. Using the TriNetX Research Network, we performed a retrospective cohort study to evaluate the risk of developing an initial kidney stone in men based on their total testosterone level. Men aged ≥18 were divided into a low testosterone (<300 ng/dL) and normal testosterone (≥ 300 ng/dL) cohort. Men were excluded if they had a history of a kidney stone encounter diagnosis before testosterone measurement and a history of testosterone therapy prescription at any point. Propensity score matching was employed with an absolute standardized mean difference of

SUBMITTER: Thompson A 

PROVIDER: S-EPMC12367534 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature