Dynamic basal ganglia output signals license and suppress forelimb movements.

ABSTRACT: The basal ganglia are fundamental to motor control and their dysfunction is linked to motor deficits^1-8. Influential investigations on the primate oculomotor system posited that movement generally depends on transient pauses of tonically firing inhibitory basal ganglia output neurons releasing brainstem motor centres^9,10. However, prominent increases in basal ganglia output neuron firing observed during other motor tasks cast doubts on the proposed mechanisms of movement regulation through basal ganglia circuitry^11-22. Here we show that basal ganglia output neurons in the mouse substantia nigra pars reticulata (SNr) represent complex forelimb movements with highly granular and dynamic changes in spiking activity, tiling task execution at the population leve

SUBMITTER: Falasconi A 

PROVIDER: S-EPMC12367548 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature