Selective remodelling of the adipose niche in obesity and weight loss.

ABSTRACT: Weight loss significantly improves metabolic and cardiovascular health in people with obesity^1-3. The remodelling of adipose tissue (AT) is central to these varied and important clinical effects⁴. However, surprisingly little is known about the underlying mechanisms, presenting a barrier to treatment advances. Here we report a spatially resolved single-nucleus atlas (comprising 171,247 cells from 70 people) investigating the cell types, molecular events and regulatory factors that reshape human AT, and thus metabolic health, in obesity and therapeutic weight loss. We discover selective vulnerability to senescence in metabolic, precursor and vascular cells and reveal that senescence is potently reversed by weight loss. We define gene regulatory mechanisms and tissue si

SUBMITTER: Miranda AMA 

PROVIDER: S-EPMC12367556 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature