Dataset Information
METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Tang B
PROVIDER: S-EPMC12367607 | biostudies-literature | 2025 Aug
REPOSITORIES: biostudies-literature
Publications
METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells.
Discover oncology 20250821 1
METTL3 and METTL14, key components of the m6A methyltransferase complex, have been extensively studied in the context of various cancers. However, their roles in regulating alternative splicing in pancreatic cancer remain largely unexplored. In this study, we analyzed high-throughput RNA-seq data (GSE146806), alongside CLIP-seq datasets (GSE132306 and SRP163326), to investigate the molecular mechanisms underlying METTL3_14-mediated regulation. The results of differentially expressed genes (DEG) ...[more]