Investigating size and surface modification to optimise the delivery of nanodiamonds to brain glial cells.

ABSTRACT: Nanodiamonds (NDs) with nitrogen-vacancy (NV) defects have garnered attention as promising nano-quantum sensors due to their high photostability, low biotoxicity, and ability to measure intracellular parameters such as temperature, magnetic fields, and electric fields. While NDs have been extensively studied in in vitro systems, their application in vivo remains underdeveloped. Efficient delivery of NDs to specific cells within biological tissues remains a critical challenge for advancing their applications in the life sciences. In this study, we investigated the intracellular uptake of NDs by glial cells (microglia and astrocytes) in the brain. Twelve types of NDs, differing in size (50 nm, 150 nm, 250 nm, and 350 nm) and surface modification (COOH, HPG and HPG-COOH), were locally injecte

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC12367616 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature