Systems pharmacology-based optimization of Ma Xing Shi Gan components for the enhanced treatment of chick health issues caused by infectious bronchitis virus.

ABSTRACT:

Introduction

Infectious bronchitis virus (IBV) imposes severe economic burdens on the poultry industry, and current treatments face challenges in efficacy and sustainability, necessitating the development of novel therapeutic strategies. To address this, this study employed the Traditional Chinese Medicine Inheritance Computing Platform (TCMICS) to collect clinical prescriptions for IBV treatment, based on which two optimized versions of the traditional Chinese medicine Maxing Shigan Decoction (MXSG), namely MXSG-mix1 and MXSG-mix2, were designed. In vitro cell culture and in vivo chicken model experiments were then carried out, including egg testing, clinical symptom observation, immune function analysis, and viral load quantification, to assess the antiviral activity of the optim

SUBMITTER: Liu H 

PROVIDER: S-EPMC12367666 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature