Inflammation-profiling reveals activated pathways and biomarkers with predictive potential in oligoarticular juvenile idiopathic arthritis.

ABSTRACT: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation profiles of 38 plasma and 62 synovial fluid (SF) oJIA samples, 38 plasma samples from healthy age- and sex-matched controls (HC), 12 SF samples from non-arthritic controls and 26 SF samples from knee injury patients. Clinical data for the oJIA cohort were retrieved from the Swedish pediatric rheumatology quality register and medical charts. Plasma inflammation profiles of oJIA and HC were largely overlapping, with IL6 a

SUBMITTER: Wen X 

PROVIDER: S-EPMC12367756 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature