Distinct humoral responses induced by heterologous versus homologous prime-boost immunization strategies in early life.

ABSTRACT: An important component in the development of efficacious vaccines is the optimization of vaccination schedules to elicit protective immunity, especially in a vulnerable group like infants. Mucosal IgA plays an important role in the initial defense at mucosal surfaces, protecting against the colonization of respiratory pathogens, potentially reducing invasion and disease severity, while systemic immunity relies on protective IgG antibodies (Abs). This study aims to design an immunization strategy inducing both optimal systemic and mucosal immune responses using heterologous prime-boost immunization in comparison to homologous immunization. We immunized neonatal mice with a pneumococcal conjugate vaccine, Pn1-CRM197, by heterologous subcutaneous (s.c.) priming with CAF01 adjuvant, followed b

SUBMITTER: Foroutan Pajoohian P 

PROVIDER: S-EPMC12367788 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature