Prioritisation of co-formulants and plant protection products for non-dietary risk assessment using NAMs.

ABSTRACT: Plant protection products (PPPs) contain one or more active substances (AS) as well as a varying number of co-formulants. Whilst AS are amongst the most data-rich and well-investigated substances in toxicology, possibly toxic co-formulants and PPPs with potentially relevant mixture effects are not considered in risk assessment. This especially applies to operators who come in contact with the undiluted product. In this study, we investigated this concern by prioritising co-formulants and PPPs for further testing using new approach methodologies (NAMs). We combined in silico predictions of co-formulant nephrotoxicity and hepatotoxicity with AS and co-formulant kinetic interaction prediction and thus identified 427 PPPs for further investigation. In a next step, six PPPs were there assessed

SUBMITTER: Stagkos-Georgiadis A 

PROVIDER: S-EPMC12367827 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature