In vitro CB₁ receptor activity of halogenated indazole synthetic cannabinoid receptor agonists.

ABSTRACT: Synthetic cannabinoid receptor agonists (SCRAs) are a group of new psychoactive substances (NPS) that bind to and activate the cannabinoid 1 and 2 (CB₁ and CB₂) receptors. Following the introduction of SCRA analog controls in China in July 2021, new SCRAs with a bromine at the 5 position on the indazole core emerged on the recreational drug market. In this study, the in vitro CB₁ receptor activity of 19 different SCRAs with a halogenated indazole core was systematically examined using a AequoScreen^® CB₁ assay alongside four available non-halogenated analogs, ADB-BUTINACA, MDMB-BUTINACA, MDMB-4en-PINACA, and MDMB-INACA, and the newly emerged MDMB-5'Me-INACA (MDMB-5-methyl-INACA). Of SCRAs with a substitution at the 5 position on the ind

SUBMITTER: Green H 

PROVIDER: S-EPMC12367851 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature