Influence of particle size on metal release from a cobalt- and nickel-containing alloy powder in an in vitro surrogate gastric fluid.

ABSTRACT: When matrix effects are present in alloys, the content of the metal ingredients is no longer reliable to predict the metal ion release and hence toxicity. Thus, the metals' industry proposed an alternative concept for self-classification based on the comparison of the metal releases between alloys and their ingredients; this approach better reflects the toxicity of the alloys when matrix effects are present. Samples of alloy and ingredients (reference) often differ in particle size. This study assessed the impact of particle sizes on cobalt (Co) and nickel (Ni) releases from different particle size fractions of an alloy powder, following a bioelution gastric fluid protocol. Results were considered together with those from reference pure Co and Ni powders. Co-release per gram of alloy incre

SUBMITTER: Oller AR 

PROVIDER: S-EPMC12367862 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature