Discovering a predictive metabolic signature of drug-induced structural cardiotoxicity in cardiac microtissues.

ABSTRACT: Improved prediction of drug-induced structural cardiotoxicity is required to reduce attrition driven by cardiac safety concerns in drug discovery. Omics measurements are well suited to this need, offering the potential to discover molecular signatures associated with toxicological endpoints. In addition, untargeted metabolomics can simultaneously measure xenobiotic fate within the test system. We present an extensive metabolomics study to discover a predictive metabolic signature of drug-induced structural cardiotoxicity. A human-relevant in vitro cardiac model, cardiac microtissues, were exposed to twelve xenobiotics (eight clinically labelled structural cardiotoxins and four non-cardiotoxic pharmaceuticals), each at two concentrations, for 6, 24, and 48 h. The measurements were made by d

SUBMITTER: Bowen TJ 

PROVIDER: S-EPMC12367874 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature