Interaction between coffee consumption and polygenic risk score in relation to diabetes: insights from the Maastricht study.

ABSTRACT: This study investigated the associations of polygenic risk score (PRS) and coffee consumption, as well as their interaction, with prediabetes and type 2 Diabetes Mellitus (T2DM) among participants in the southern Netherlands. 7668 participants were classified as normal glucose metabolism (NGM), prediabetes, or T2DM based on World Health Organization 2006 criteria. PRS (423 T2DM-related single nucleotide polymorphisms) and coffee consumption (via food frequency questionnaire) were categorized into tertiles (low, medium, and high) based on the population distribution. Multinomial logistic regression and dose-response analyses were performed to evaluate the cross-sectional associations between PRS and coffee consumption with prediabetes and T2DM. Fully adjusted analyses indicated that medium

SUBMITTER: Rao Y 

PROVIDER: S-EPMC12367902 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature