Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia.

ABSTRACT: Levodopa induced dyskinesia (LID) is a serious side effect of levodopa treatment in Parkinson's disease (PD), with limited interventions. Understanding the genetic impact on LID would help inform future intervention studies. We performed integrative genomic analysis approaches to identify the genetic determinants of LID in a Chinese multi-center prospective, observational PD cohort. In this cohort, 46 of 315 PD patients developed LID during 2.5 years of follow-up. First, we performed a genome-wide association study (GWAS) in this cohort, followed by a meta-analysis integrating our GWAS summary data with additional data of European ancestry. Both GWAS analyses identified the Bromodomain Containing 3 (BRD3) as a LID susceptibility gene (P < 5 × 10^-8); however, the genetic variants

SUBMITTER: Wan Y 

PROVIDER: S-EPMC12367974 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature