NMR based clinical metabolomics revealed altered lipid and sugar metabolism in systemic sclerosis with implications for diagnosis and therapeutic strategies.

ABSTRACT: Systemic Sclerosis (SSc) is a complex autoimmune disorder characterized by vascular dysfunction, immune dysregulation, and progressive fibrosis of the skin and internal organs. Despite substantial research, its pathophysiology remains enigmatic, necessitating the identification of altered metabolic pathways to improve disease management. This study utilized NMR-based serum metabolomics to identify distinctive metabolic signatures and deranged pathways in SSc. 1D 1H CPMG spectra of sera from 83 SSc patients and 43 age/sex matched HC were measured using 800 MHz NMR. Spectral binning and concentration profiling data were analyzed using multivariate statistical analysis to identify discriminatory metabolic features based variable importance in projection (VIP) scores and mean decrease accuracy

SUBMITTER: Singh G 

PROVIDER: S-EPMC12368016 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature