Computational and experimental discovery of peptide inhibitors targeting survivin for therapeutic potential in cancer.

ABSTRACT: Evidence indicates that the survivin protein is overexpressed in various types of cancer. Survivin belongs to the inhibitors of apoptosis proteins (IAPs) family, which plays a crucial role in preventing apoptosis and regulating the cell cycle. This protein has a multifaceted function in the cell cycle, particularly in regulating mitosis and cytokinesis. Survivin binds to XIAP, enhancing its stability, and interactively inhibiting caspase-9 activity. Additionally, survivin inhibits apoptosis by inactivating the Smac/DIABLO factor. In this study, we investigated the dual role of peptides in disrupting cell division and inducing apoptosis. Specifically, we designed anti-cancer peptides derived from the Borealin protein. Through single-point mutations, we developed several peptide variants and

SUBMITTER: Ahmadi SF 

PROVIDER: S-EPMC12368056 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature